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We created bug 31966174 with Oracle regarding PO modification. Right now, anybody can modify a PO (change price, quantities) that was created by someone else, even if they do not have an approval route under their originator number. The approval route on the PO header will apply and there is no processing option to change that.
How do you handle that at your sites? In order to follow procurement rules, only those that have an approval route set-up for them should be able to create and modify a PO.
You are correct, there is no "switch" in processing options to prevent people from changing someone else's POs. If someone changes a PO, the approval route will change to the approval route of the person who made the change.
Since only buyers should have update access to purchase orders; all others should have just inquiry only access.
Then it becomes an educational issues with your buyers.
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